Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
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Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 ...
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The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmin...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2010
ISSN: 1942-0900,1942-0994
DOI: 10.4161/oxim.3.5.13109